Intratumoral Electroporation Delivery Systems

Inovio's MedPulser® DNA Delivery System, consisting of a pulse generator and needle electrode applicator, was designed to create conditions to deliver DNA into tumor cells that promote optimal responses to gene-based immunotherapeutic cytokines. The cytokine-encoding plasmid is first injected with a syringe/needle into the selected tumor. Using a remote control, the pulse generator is switched on. High-voltage electrical pulses are generated and delivered through an attached electrical cord into the injected tissue through an electrode-needle array on the applicator. The electrode-needle array consists of two sets of opposite needle pairs, or a total of four needle-electrodes. The needle-electrode arrays are available in different sizes and configurations to facilitate access to tumors of different sizes and in different locations.

Output characteristics: 400-1500V/cm, 99μs