Intramuscular Electroporation Delivery Systems

MedPulser® DNA Delivery System

Inovio's MedPulser® DNA Delivery System, consisting of a pulse generator and needle electrode applicator, was designed to create optimal conditions to deliver DNA into muscle cells for immunization. The vaccine is first injected with a syringe/needle into selected muscle tissue, usually the deltoid muscle that is used for conventional flu vaccines. Using a remote control, the pulse generator is switched on. Low-voltage electrical pulses are generated and delivered through an attached electrical cord into the injected tissue through an electrode-needle array on the applicator. The electrode-needle array consists of two sets of opposite needle pairs, or a total of four needle-electrodes. The needle-electrode array is removable and disposable to reduce costs. The arrays are available in different sizes, using different voltage pulses from the generator to create the optimal field strength.

Output characteristics: 50-250V/cm, 60ms

Elgen® DNA Delivery System

The Elgen® DNA Delivery System is the newest generation of electroporation systems developed by Inovio. The system consists of a pulse generator and needle-electrode applicator that incorporates two syringes/needles. With the pressing of two buttons on the integrated applicator, the two needles are inserted into the selected muscle tissue, DNA vaccine is injected, and electrical pulses are applied. Low-voltage electrical pulses are generated by the pulse generator and delivered through an attached electrical cord into the same selected tissue through the electrode-needle pair on the applicator, effectively co-localizing the DNA and the porating electric field.

Output characteristics: 50-250V/cm, 10-60ms