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Electroporation-Based DNA Delivery
Electroporation is emerging as a preferred method for delivering DNA-based agents
Most drugs and all genes act on cellular machinery inside a cell in order to perform their intended function. Getting these agents through the cell membrane can be a significant challenge. Electroporation uses controlled, millisecond electrical pulses to create permeability in the cell membrane and enable dramatic uptake of a biological material previously injected into the same local tissue.
Inovio's electroporation-based DNA delivery technology for DNA plasmid-based immunotherapies and DNA vaccines has displayed the following characteristics:
- Dramatically enhances cellular uptake of biological materials such as DNA vaccines
- Can induce significant immune responses, including antibody and T-cell responses
- Tolerable without anesthetic
- DNA plasmids used in conjunction with electroporation are easily, cost effectively manufactured, without manufacturing complexities
- Does not induce unwanted immune responses against the delivery mechanism, therefore can be used for repeat administration of vaccines, e.g. for booster shots.