Inovio Product Pipeline: Selective Electrochemical Tumor Ablation
Inovio's Selective Electrochemical Tumor Ablation (SECTA) therapy using its core electroporation technology in conjunction with a chemotherapeutic agent called bleomycin. The SECTA therapy for locally treating solid tumors is designed to selectively kill cancerous cells and minimize cosmetic or functional detriments often caused by surgical removal of predominantly healthy tissue typically treated around a tumor.
Phase III clinical trials in recurrent head & neck cancer
- Stopped enrollment and conducting interim analysis based on recommendation by data monitoring committee
Two European pre-marketing clinical studies
- Head & neck cancers: enrolled 92 patients, conducting data analysis
- Skin cancers: enrolled 89 patients, conducting data analysis
Phase I/II recurrent breast cancer study
- Enrolled 13 patients, data pending
Seeking partner for spinout/divestiture and further development
Scientific Publications: Selective Electrochemical Tumor Ablation
Byrne, C., Thompson, J.F. Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors. Expert review of anticancer therapy Vol 6, Issue 5, pp. 671-8, 2006
Byrne, C., Thompson, J.F., Johnston, H., Hersey, P., Quinn, M.J., Hughes, T.M., McCarthy, W.H. Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy). Melanoma Research Vol 15 No 1, 2005.
Bloom, D.C., Goldfarb, P.M. The role of intratumour therapy with the electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck. European Journal of Surgical Oncology 31, 1029 – 1035, 2005
Burian, M., Formanek, M., Regele, H. Electroporation therapy in head and neck cancer. Acta Otolaryngol; 123: 264-268, 2003.
Krassowka, W., Nanda, S. N., Austin, M. B., Dev, S. B., Rabussay, D. P. Viability of cancer cells exposed to pulsed electric fields: The role of pulse charge. Annals of Biomedical Engineering 31:80-90, 2003.
Rabussay, D. P., Nanda, G. S., Goldfarb, P. M. Enhancing the effectiveness of drug-based cancer therapy by electroporation (electropermeabilization). Technology in Cancer Research & Treatment, 1(1):71-82, 2002.
Dev, S. B., Caban, J. B., Nanda, G. S., Bleecher, S. D., Rabussay, D. P., Moerland, T. S., Gibbs, S. J., Locke, B. R. Magnetic resonance studies of laryngeal tumors in nude mice: effect of treatment with bleomycin and electroporation. Magnetic Resonance Imaging 20:389-394, 2002.
Nanda, G.S., Bleecher, S., Dev, S.B., Rabussay, D.P. Electroporation therapy of head and neck tumors. Oral Oncology, Vol VII, A.K. Varma and J.L.N. Roodenburg (eds.) Macmillian India, Ltd., 318-322, 2001.
Nanda, G.S., Rabussay, D.P. Safety of head and neck tumor treatment by electroporation therapy: Effect on healthy tissues. Oral Oncology, Vol VII, A.K. Varma and J.L.N. Roodenburg (eds.) Mackmillian India, Ltd., 326-331, 2001.
Dev, S.B., Hofmann, G.A. and Nanda, G.S. Treatment of human pancreatic tumors xenografted in nude mice by chemotherapy combined with pulsed electric fields. In: Methods in Molecular Medicine Vol. 37, Ch. 17, pp. 277-283, M.J. Jaroszeski, R. Heller, and R. Gilbert, eds., Humana Press, Inc., Totowa, NJ, 2000.
Hofmann, G.A., Dev, S.B., Dimmer, S. and Nanda, G.S. Electroporation therapy: A new approach for the treatment of head and neck cancer. IEEE Transactions on Biomedical Engineering, 46(6):752-759, 1999.
Hofmann, G.A., Dev, S.B., Nanda, G.S., Rabussay, D. Electroporation of Solid tumors. Critical Reviews in Therapeutic Carrier Systems. 16(6):523-569, 1999.
Nanda, G.S., Sun, F.X., Hofmann, G.A., Hoffman, R.M. and Dev, S.B. Electroporation enhances therapeutic efficacy of anticancer drugs: Treatment of human pancreatic tumor in animal model. Anticancer Research, 18:1361-1366, 1998.
Nanda, G.S., Sun, F.X., Hofmann, G.A., Hoffman, R.M. and Dev, S.B. Electroporation therapy of human larynx tumors Hep-2 implanted in nude mice. Anticancer Research, 18:999-1004, 1998.
Dev, S.B., Nanda, G.S., An, Z., Wang, X., Hoffman, R.M. and Hofmann, G.A. Effective electroporation therapy of human pancreatic tumors implanted in nude mice. Drug Delivery, 4:293-299, 1997.
Dev, S.B. Electrochemotherapy for cancer. Cancer Watch, 5(2):23-24, 1996.
Hofmann, G.A., Dev, S.B. and Nanda, G.S. Engineering in genomics. Electrochemotherapy: Transition from laboratory to the clinic. IEEE Engineering in Medicine and Biology, Nov./Dec., pp124-132, 1996.
Dev, S.B. Killing cancer cells with a combination of pulsed electric fields and chemotherapeutic agents. Cancer Watch, 3(1):12-14, 1994.
Dev, S.B. and Hofmann, G.A. Electrochemotherapy - a novel method of cancer treatment. Cancer Treatment Reviews, 20:105-115, 1994.
Dev, S.B. and Kornhauser, S.H. Electrochemotherapy. Medical Electronics, September 1994.